Institute of Medicine, Chung Shan Medical University, Taichung 40242, Taiwan, China.
World J Gastroenterol. 2012 Sep 28;18(36):5090-5. doi: 10.3748/wjg.v18.i36.5090.
To investigate the symptom presentation and quality of life in obese Chinese patients with gastroesophageal reflux disease (GERD).
Data from patients diagnosed with GERD according to the Montreal definition, were collected between January 2009 to March 2010. The enrolled patients were assigned to the normal [body mass index (BMI) < 25 kg/m(2)], overweight (25-30 kg/m(2)), and obese (BMI > 30 kg/m(2)) groups. General demographic data, endoscopic findings, and quality of life of the three groups of patients were analyzed and compared.
Among the 173 enrolled patients, 102, 56 and 15 patients were classified in the normal, overweight, and obese, respectively. There was significantly more erosive esophagitis (73.3% vs 64.3% vs 39.2%, P = 0.002), hiatal hernia (60% vs 33.9% vs 16.7%, P = 0.001), and males (73.3% vs 73.2% vs 32.4%, P = 0.001) in the obese cases. The severity and frequency of heartburn, not acid regurgitation, was positively correlated with BMI, with a significant association in men, but not in women. Obese patients were prone to have low quality of life scores, with obese women having the lowest scores for mental health.
In patients with GERD, obese men had the most severe endoscopic and clinical presentation. Obese women had the poorest mental health.
调查肥胖的胃食管反流病（GERD）患者的症状表现和生活质量。
根据蒙特利尔定义，收集了 2009 年 1 月至 2010 年 3 月期间诊断为 GERD 的患者的数据。将纳入的患者分为正常（体重指数（BMI）<25kg/m2）、超重（25-30kg/m2）和肥胖（BMI>30kg/m2）组。分析和比较三组患者的一般人口统计学数据、内镜检查结果和生活质量。
在 173 名纳入患者中，102、56 和 15 名患者分别归类于正常、超重和肥胖组。肥胖组中更易出现糜烂性食管炎（73.3%比 64.3%比 39.2%，P=0.002）、食管裂孔疝（60%比 33.9%比 16.7%，P=0.001）和男性（73.3%比 73.2%比 32.4%，P=0.001）。烧心的严重程度和频率，而非酸反流，与 BMI 呈正相关，在男性中存在显著关联，但在女性中则无。肥胖患者的生活质量评分较低，肥胖女性的心理健康评分最低。
在 GERD 患者中，肥胖男性的内镜和临床表现最严重。肥胖女性的心理健康最差。
