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成纤维细胞生长因子和转化生长因子β抑制肌源性调节基因MyoD1的转录。

Fibroblast growth factor and transforming growth factor beta repress transcription of the myogenic regulatory gene MyoD1.

作者信息

Vaidya T B, Rhodes S J, Taparowsky E J, Konieczny S F

机构信息

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

出版信息

Mol Cell Biol. 1989 Aug;9(8):3576-9. doi: 10.1128/mcb.9.8.3576-3579.1989.

DOI:10.1128/mcb.9.8.3576-3579.1989
PMID:2797000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362410/
Abstract

In this report, we demonstrate that myogenic cultures inhibited from differentiating by treatment with fibroblast growth factor or transforming growth factor beta show reduced levels of MyoD1 mRNA. Although this repression may contribute to the inhibition of myogenesis by growth factors, additional regulatory pathways must be affected, since inhibition still occurs in cultures engineered to constitutively express MyoD1 mRNA.

摘要

在本报告中，我们证明，用成纤维细胞生长因子或转化生长因子β处理后受到分化抑制的生肌培养物中，MyoD1 mRNA水平降低。虽然这种抑制作用可能有助于生长因子对肌生成的抑制，但必定还有其他调控途径受到影响，因为在经基因工程改造而组成性表达MyoD1 mRNA的培养物中，抑制作用仍然会出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/348e9d975de9/molcellb00056-0434-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/be83808eed58/molcellb00056-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/c984ed2d0495/molcellb00056-0433-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/4532d53a5e36/molcellb00056-0433-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/c70a1bf121c6/molcellb00056-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/348e9d975de9/molcellb00056-0434-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/be83808eed58/molcellb00056-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/c984ed2d0495/molcellb00056-0433-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/4532d53a5e36/molcellb00056-0433-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/c70a1bf121c6/molcellb00056-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39ff/362410/348e9d975de9/molcellb00056-0434-b.jpg

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