Tsujimoto H, Hasegawa A, Maki N, Fukasawa M, Miura T, Speidel S, Cooper R W, Moriyama E N, Gojobori T, Hayami M
Department of Animal Pathology, University of Tokyo, Japan.
Nature. 1989 Oct 12;341(6242):539-41. doi: 10.1038/341539a0.
Since the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVMAC), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
自从从圈养猕猴（SIVMAC）中分离出一种与HIV-2相关的病毒以来，人类免疫缺陷病毒的起源这一备受争议的话题就被归因于猴子。源自自然感染的非洲绿猴的SIVAGM序列与HIV-1和HIV-2的亲缘关系相同，这表明这些病毒不太可能源自SIVAGM。然而，最近对圈养的乌黑白眉猴（SIVMAC）的SIV进行的序列分析表明，它与HIV-2和SIVMAC密切相关，这表明HIV-2和SIVMAC可能起源于SIVSM（参考文献4、7、9）。我们在此报告从非洲野生捕获的山魈中分离出的一种新型猿猴慢病毒SIVMND的序列。它与其他三个主要群体HIV-1、HIV-2/SIVMAC/SIVSM和SIVAGM不同，因此代表了灵长类慢病毒的第四个主要群体。系统发育分析表明，这四个主要病毒群体可能在大约同一时间从一个共同祖先分化而来，这比艾滋病在人类中传播要早得多。
