Fukasawa M, Miura T, Hasegawa A, Morikawa S, Tsujimoto H, Miki K, Kitamura T, Hayami M
Department of Animal Pathology, University of Tokyo, Japan.
Nature. 1988 Jun 2;333(6172):457-61. doi: 10.1038/333457a0.
Some wild African green monkeys are known to be naturally infected with a retrovirus related to human immunodeficiency virus (HIV) without having any apparent symptoms of an AIDS-like disease. This simian immunodeficiency virus, designated SIVAGM, may be helpful in clarifying the evolution and pathogenicity of HIV. Some virus strains that were previously reported to be isolated from African green monkeys were shown to be laboratory contaminations of SIVMAC (SIV from a rhesus macaque) Here we report the complete DNA sequence of authentic SIVAGM, which was isolated from a naturally infected African green monkey of Kenyan origin. Comparison of the genome of SIVAGM with those of known HIV/SIVs indicates that the virus is a new simian lentivirus that is approximately equally distantly related to HIV-1 and HIV-2 in contrast to SIVMAC, which is much closer to HIV-2 than to HIV-1 (refs 5, 9).
已知一些野生非洲绿猴自然感染了一种与人类免疫缺陷病毒（HIV）相关的逆转录病毒，却没有任何类似艾滋病疾病的明显症状。这种猿猴免疫缺陷病毒，命名为SIVAGM，可能有助于阐明HIV的进化和致病性。一些先前报道从非洲绿猴中分离出的病毒株被证明是SIVMAC（恒河猴来源的SIV）的实验室污染物。在此我们报告了从一只源自肯尼亚的自然感染非洲绿猴中分离出的正宗SIVAGM的完整DNA序列。将SIVAGM的基因组与已知HIV/SIV的基因组进行比较表明，该病毒是一种新的猿猴慢病毒，与HIV-1和HIV-2的亲缘关系大致相等，而SIVMAC与HIV-2的亲缘关系比与HIV-1的亲缘关系更近（参考文献5、9）。
