Falagan-Lotsch Priscila, Grzincic Elissa M, Murphy Catherine J
Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Bioconjug Chem. 2017 Jan 18;28(1):135-152. doi: 10.1021/acs.bioconjchem.6b00591. Epub 2017 Jan 4.
Breast cancer is a major cause of suffering and mortality among women. Limitations in the current diagnostic methods and treatment approaches have led to new strategies to positively impact the survival rates and quality of life of breast cancer patients. Nanotechnology offers a real possibility of mitigating breast cancer mortality by early-stage cancer detection and more precise diagnosis as well as more effective treatments with minimal side effects. The current nanoplatforms approved for breast cancer therapeutics are based on passive tumor targeting using organic nanoparticles and have not provided the expected significant improvements in the clinic. In this review, we present the emerging approaches in breast cancer nanomedicine based on active targeting using versatile inorganic nanoplatforms with biomedical relevance, such as gold, silica, and iron oxide nanoparticles, as well as their efficacy in breast cancer imaging, drug and gene delivery, thermal therapy, combinational therapy, and theranostics in preclinical studies. The main challenges for clinical translation and perspectives are discussed.
乳腺癌是女性痛苦和死亡的主要原因。当前诊断方法和治疗手段的局限性促使了新策略的产生，以积极影响乳腺癌患者的生存率和生活质量。纳米技术提供了通过早期癌症检测、更精确的诊断以及副作用最小的更有效治疗来降低乳腺癌死亡率的切实可能性。目前已获批用于乳腺癌治疗的纳米平台基于使用有机纳米颗粒的被动肿瘤靶向，尚未在临床上带来预期的显著改善。在本综述中，我们介绍了基于使用具有生物医学相关性的多功能无机纳米平台（如金、二氧化硅和氧化铁纳米颗粒）进行主动靶向的乳腺癌纳米医学新方法，以及它们在临床前研究中在乳腺癌成像、药物和基因递送、热疗、联合治疗和诊疗方面的功效。还讨论了临床转化面临的主要挑战和前景。
