Bhat Shahnawaz Ahmad, Kumar Vijay, Dhanjal Daljeet Singh, Gandhi Yashika, Mishra Sujeet K, Singh Simranjeet, Webster Thomas J, Ramamurthy Praveen C
Jamia Milia Islamia, New Delhi, 110011, India.
Central Ayurveda Research Institute, Jhansi, U.P., 284003, India.
Discov Nano. 2024 Aug 3;19(1):121. doi: 10.1186/s11671-024-04072-y.
Breast cancer, a widespread malignancy affecting women globally, often arises from mutations in estrogen/progesterone receptors. Conventional treatments like surgery, radiotherapy, and chemotherapy face limitations such as low efficacy and adverse effects. However, nanotechnology offers promise with its unique attributes like targeted delivery and controlled drug release. Yet, challenges like poor size distribution and environmental concerns exist. Biogenic nanotechnology, using natural materials or living cells, is gaining traction for its safety and efficacy in cancer treatment. Biogenic nanoparticles synthesized from plant extracts offer a sustainable and eco-friendly approach, demonstrating significant toxicity against breast cancer cells while sparing healthy ones. They surpass traditional drugs, providing benefits like biocompatibility and targeted delivery. Thus, this current review summarizes the available knowledge on breast cancer (its types, stages, histopathology, symptoms, etiology and epidemiology) with the importance of using biogenic nanomaterials as a new and improved therapy. The novelty of this work lies in its comprehensive examination of the challenges and strategies for advancing the industrial utilization of biogenic metal and metal oxide NPs. Additionally; it underscores the potential of plant-mediated synthesis of biogenic NPs as effective therapies for breast cancer, detailing their mechanisms of action, advantages, and areas for further research.
乳腺癌是一种影响全球女性的广泛恶性肿瘤，通常由雌激素/孕激素受体的突变引起。手术、放疗和化疗等传统治疗方法存在疗效低和副作用等局限性。然而，纳米技术因其靶向递送和控释药物等独特特性而带来了希望。然而，也存在尺寸分布不佳和环境问题等挑战。生物源纳米技术利用天然材料或活细胞，因其在癌症治疗中的安全性和有效性而越来越受到关注。由植物提取物合成的生物源纳米颗粒提供了一种可持续且环保的方法，对乳腺癌细胞具有显著毒性，同时对健康细胞无害。它们优于传统药物，具有生物相容性和靶向递送等优点。因此，本综述总结了关于乳腺癌的现有知识（其类型、阶段、组织病理学、症状、病因和流行病学）以及使用生物源纳米材料作为一种新的改良疗法的重要性。这项工作的新颖之处在于其对推进生物源金属和金属氧化物纳米颗粒工业应用的挑战和策略进行了全面研究。此外，它强调了植物介导合成生物源纳米颗粒作为乳腺癌有效治疗方法的潜力，详细阐述了它们的作用机制、优点和进一步研究的领域。
