Hersant Barbara, SidAhmed-Mezi Mounia, La Padula Simone, Niddam Jeremy, Bouhassira Jonathan, Meningaud Jean Paul
Department of Plastic and Cosmetic Reconstructive Surgery, Henri Mondor Hospital, Créteil, France.
Plast Reconstr Surg Glob Open. 2016 Nov 15;4(11):e871. doi: 10.1097/GOX.0000000000000823. eCollection 2016 Nov.
Seroma and hematoma formations are the most common complications after plastic surgery. The aim of this study was to assess the efficacy of autologous platelet-rich plasma (A-PRP) glue to reduce postoperative wound complications and improve surgical outcomes.
Fifty-four patients were included in this study. They underwent breast reduction surgery, abdominoplasty, or limb lifting with A-PRP glue application on the entire surface of the subcutaneous tissue at the time of suture. Retrospective data were used for the control group. The primary endpoint was the incidence of postoperative seroma or hematoma. The secondary endpoint was the Patient and Observer Scar Assessment Scale score.
Demographics and clinical characteristics were not statistically different between the A-PRP glue group and the control group regarding age, sex ratio, and body mass index. After abdominoplasty, 37.5% of patients (3/8) in the control group experienced seroma and hematoma complications versus 12.5% of patients (2/16) in the A-PRP glue group ( = 0.55 and = 0.25, respectively). After limb lifting, 50% of patients experienced postoperative complications in the control group versus no patient in the A-PRP glue group ( = 0.03*; * indicates that the value is significant). After breast reduction, no patient experienced complication in the A-PRP glue group versus 25% of patients in the control group who experienced hematoma ( = 0.04*). The scar quality assessed 12 months after surgery showed no statistical differences between the groups.
A-PRP glue seems effective to prevent seroma formation after limb lifting and hematoma formation after breast reduction. Wound-healing quality did not seem to be improved.
血清肿和血肿形成是整形手术后最常见的并发症。本研究的目的是评估自体富血小板血浆（A-PRP）胶水在减少术后伤口并发症和改善手术效果方面的疗效。
本研究纳入了54例患者。他们接受了乳房缩小术、腹部整形术或肢体提升术，在缝合时将A-PRP胶水应用于皮下组织的整个表面。对照组采用回顾性数据。主要终点是术后血清肿或血肿的发生率。次要终点是患者和观察者瘢痕评估量表评分。
A-PRP胶水组和对照组在年龄、性别比例和体重指数方面的人口统计学和临床特征无统计学差异。腹部整形术后，对照组37.5%的患者（3/8）出现血清肿和血肿并发症，而A-PRP胶水组为12.5%的患者（2/16）（分别为 = 0.55和 = 0.25）。肢体提升术后，对照组50%的患者出现术后并发症，而A-PRP胶水组无患者出现（ = 0.03*；表示 值具有显著性）。乳房缩小术后，A-PRP胶水组无患者出现并发症，而对照组25%的患者出现血肿（ = 0.04）。术后12个月评估的瘢痕质量在两组之间无统计学差异。
A-PRP胶水似乎对预防肢体提升术后血清肿形成和乳房缩小术后血肿形成有效。伤口愈合质量似乎没有得到改善。
