一种用于马尔堡病毒感染的仓鼠模型准确再现了马尔堡出血热。
A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever.
机构信息
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Sci Rep. 2016 Dec 15;6:39214. doi: 10.1038/srep39214.
Marburg virus (MARV), a close relative of Ebola virus, is the causative agent of a severe human disease known as Marburg hemorrhagic fever (MHF). No licensed vaccine or therapeutic exists to treat MHF, and MARV is therefore classified as a Tier 1 select agent and a category A bioterrorism agent. In order to develop countermeasures against this severe disease, animal models that accurately recapitulate human disease are required. Here we describe the development of a novel, uniformly lethal Syrian golden hamster model of MHF using a hamster-adapted MARV variant Angola. Remarkably, this model displayed almost all of the clinical features of MHF seen in humans and non-human primates, including coagulation abnormalities, hemorrhagic manifestations, petechial rash, and a severely dysregulated immune response. This MHF hamster model represents a powerful tool for further dissecting MARV pathogenesis and accelerating the development of effective medical countermeasures against human MHF.
马尔堡病毒（MARV）是埃博拉病毒的近亲，是一种严重人类疾病——马尔堡出血热（MHF）的病原体。目前尚无治疗 MHF 的许可疫苗或疗法，因此 MARV 被归类为一级选择剂和 A 类生物恐怖主义剂。为了针对这种严重疾病开发对策，需要开发能够准确再现人类疾病的动物模型。在这里，我们描述了使用适应仓鼠的 MARV 变体安哥拉开发新型、一致致死的叙利亚金黄仓鼠 MHF 模型的情况。值得注意的是，该模型显示出几乎所有在人类和非人类灵长类动物中观察到的 MHF 的临床特征，包括凝血异常、出血表现、瘀点皮疹和严重失调的免疫反应。这种 MHF 仓鼠模型代表了一种强大的工具，可以进一步剖析 MARV 发病机制，并加速针对人类 MHF 的有效医疗对策的开发。
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