Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.
German Center for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel-Riems, 38124 Braunschweig, Germany.
Viruses. 2023 Jan 4;15(1):158. doi: 10.3390/v15010158.
The order contains a variety of highly pathogenic viruses that may infect humans, including the families , , , and . Animal models have historically been important to study virus pathogenicity and to develop medical countermeasures. As these have inherent shortcomings, the rise of microphysiological systems and organoids able to recapitulate hallmarks of the diseases caused by these viruses may have enormous potential to add to or partially replace animal modeling in the future. Indeed, microphysiological systems and organoids are already used in the pharmaceutical R&D pipeline because they are prefigured to overcome the translational gap between model systems and clinical studies. Moreover, they may serve to alleviate ethical concerns related to animal research. In this review, we discuss the value of animal model alternatives in human pathogenic filovirus and bornavirus research. The current animal models and their limitations are presented followed by an overview of existing alternatives, such as organoids and microphysiological systems, which might help answering open research questions.
该订单包含多种可能感染人类的高致病性病毒，包括科、科、科和科。动物模型在研究病毒致病性和开发医疗对策方面一直具有重要意义。由于这些模型具有固有缺陷，因此能够重现这些病毒引起的疾病特征的微生理系统和类器官的出现，将来可能具有巨大的潜力来补充或部分替代动物模型。实际上，微生理系统和类器官已经用于药物研发管道中，因为它们预先设想可以克服模型系统与临床研究之间的转化差距。此外，它们可能有助于减轻与动物研究相关的伦理问题。在这篇综述中，我们讨论了动物模型替代品在人类致病性丝状病毒和博尔纳病毒研究中的价值。本文首先介绍了当前的动物模型及其局限性，然后概述了现有的替代方法，例如类器官和微生理系统，这些方法可能有助于回答未解决的研究问题。
