Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Sci Rep. 2016 Dec 15;6:39005. doi: 10.1038/srep39005.
Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu added, thereby facilitating the detection of the desired concentration range of bilirubin.
早期且便捷地检测疾病，利用即时检测且廉价的设备，不仅为早期治疗提供了选择，还降低了疾病传播的风险。在此，我们报告了一种基于胆红素的鲁棒薄膜型发光指示剂的制备方法，它可以通过患者的拇指印迹来指示高胆红素血症。该薄膜由壳聚糖稳定的金（Au）纳米团簇制成，在存在 Cu 离子时，薄膜的紫外光诱导发光强度会被有效猝灭，而在存在胆红素时则会恢复，胆红素可以来源于皮肤或血清。此外，通过添加的 Cu 离子的量可以调节检测胆红素的灵敏度，从而有助于检测所需浓度范围内的胆红素。
