Lumley Sheila, Noble Howard, Hadley Martin J, Callow Liz, Malik Amna, Chua Yi Yi, Duffey Owen J, Grolmusova Natalia, Kumar Arvind, Ravenscroft Samuel, Spencer Jonathan I, Neumann-Haefelin Christoph, Thimme Robert, Andersson Monique, Klenerman Paul, Barnes Eleanor, Matthews Philippa C
Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
IT Services, University of Oxford, Oxford, UK.
Wellcome Open Res. 2016 Nov 15;1:9. doi: 10.12688/wellcomeopenres.9952.1.
Increased clinical and scientific scrutiny is being applied to hepatitis B virus (HBV), with focus on the development of new therapeutic approaches, ultimately aiming for cure. Defining the optimum natural CD8+ T cell immune responses that arise in HBV, mediated by HLA class I epitope presentation, may help to inform novel immunotherapeutic strategies. Therefore, we have set out to develop a comprehensive database of these epitopes in HBV, coined 'Hepitopes'. This undertaking has its foundations in a systematic literature review to identify the sites and sequences of all published class I epitopes in HBV. We also collected information regarding the methods used to define each epitope, and any reported associations between an immune response to this epitope and disease outcome. The results of this search have been collated into a new open-access interactive database that is available at http://www.expmedndm.ox.ac.uk/hepitopes. Over time, we will continue to refine and update this resource, as well as inviting contributions from others in the field to support its development. This unique new database is an important foundation for ongoing investigations into the nature and impact of the CD8+ T cell response to HBV.
对乙型肝炎病毒（HBV）的临床和科学审查日益严格，重点是开发新的治疗方法，最终目标是实现治愈。确定由HLA I类表位呈递介导的HBV中出现的最佳天然CD8 + T细胞免疫反应，可能有助于为新型免疫治疗策略提供信息。因此，我们着手建立一个全面的HBV这些表位数据库，命名为“Hepitopes”。这项工作基于系统的文献综述，以确定HBV中所有已发表的I类表位的位点和序列。我们还收集了有关用于定义每个表位的方法的信息，以及任何报道的针对该表位的免疫反应与疾病结局之间的关联。这项搜索的结果已整理成一个新的开放获取交互式数据库，可在http://www.expmedndm.ox.ac.uk/hepitopes上获取。随着时间的推移，我们将继续完善和更新这个资源，并邀请该领域的其他人提供贡献以支持其发展。这个独特的新数据库是正在进行的关于CD8 + T细胞对HBV反应的性质和影响的研究的重要基础。
