兔睑板腺开口闭合后的泪膜和眼表变化

Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit.

作者信息

Gilbard J P, Rossi S R, Heyda K G

机构信息

Cornea Unit, Eye Research Institute of Retina Foundation, Harvard Medical School, Boston.

出版信息

Ophthalmology. 1989 Aug;96(8):1180-6. doi: 10.1016/s0161-6420(89)32753-9.

DOI:10.1016/s0161-6420(89)32753-9

PMID:2797721

Abstract

To determine whether meibomian gland dysfunction can increase tear film osmolarity and produce ocular surface changes analogous to those seen with lacrimal gland disease (keratoconjunctivitis sicca [KCS]), the authors closed the meibomian gland orifices in the right eyes of 11 rabbits by light cautery and studied the changes for 20 weeks. Tear film osmolarity was increased throughout the observation period. Conjunctival goblet cell density and corneal epithelial glycogen levels declined progressively. Closure of the meibomian gland orifices thus increased tear film osmolarity in the presence of normal lacrimal gland function and caused ocular surface abnormalities similar to KCS.

摘要

为了确定睑板腺功能障碍是否会增加泪膜渗透压，并产生类似于泪腺疾病（干眼症[KCS]）所见的眼表变化，作者通过轻度烧灼封闭了11只兔子右眼的睑板腺开口，并研究了20周内的变化。在整个观察期内，泪膜渗透压均升高。结膜杯状细胞密度和角膜上皮糖原水平逐渐下降。因此，在泪腺功能正常的情况下，睑板腺开口的封闭增加了泪膜渗透压，并导致了类似于干眼症的眼表异常。