兔干眼性角结膜炎模型中疾病的自然史。

Natural history of disease in a rabbit model for keratoconjunctivitis sicca.

作者信息

Gilbard J P, Rossi S R, Gray K L, Hanninen L A

机构信息

Eye Research Institute, Harvard Medical School, Boston, Massachusetts.

出版信息

Acta Ophthalmol Suppl (1985). 1989;192:95-101. doi: 10.1111/j.1755-3768.1989.tb07100.x.

DOI:10.1111/j.1755-3768.1989.tb07100.x

PMID:2554662

Abstract

We have continued our study of the tear film and ocular surface in our full KCS (keratoconjunctivitis sicca) rabbit model up to 52 weeks post-operatively. Tear film osmolarity remains elevated, conjunctival goblet cell density remains decreased, and the conjunctival epithelium remains abnormal. Corneal epithelial glycogen levels decreased progressively, and at 44 weeks post-operatively rabbits developed abnormal rose Bengal staining of the affected cornea that was shown to be associated with morphologic abnormalities at 52 weeks. Rabbits began rubbing the affected eye after the development of corneal staining. Our full KCS rabbit model demonstrates the features of the human disease.

摘要

我们持续对完全性干眼（角结膜干燥症）兔模型的泪膜和眼表进行研究，直至术后52周。泪膜渗透压持续升高，结膜杯状细胞密度持续降低，结膜上皮仍不正常。角膜上皮糖原水平逐渐下降，术后44周时，患病兔的角膜出现异常的孟加拉玫瑰红染色，且在52周时显示与形态学异常相关。角膜染色出现后，兔开始揉擦患眼。我们的完全性干眼兔模型展现出了人类疾病的特征。