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非合格供体作为减少器官短缺的策略。

Noneligible Donors as a Strategy to Decrease the Organ Shortage.

机构信息

Department of Transplant, Mayo Clinic, Jacksonville, FL.

出版信息

Am J Transplant. 2017 Jun;17(6):1649-1655. doi: 10.1111/ajt.14163. Epub 2017 Jan 31.

Abstract

Organ procurement organization (OPO) performance is generally evaluated by the number of organ procurement procedures divided by the number of eligible deaths (donation after brain death [DBD] donors aged <70 years), whereas the number of noneligible deaths (including donation after cardiac death donors and DBD donors aged >70 years) is not tracked. The present study aimed to investigate the variability in the proportion of noneligible liver donors by the 58 donor service areas (DSAs). Patients undergoing liver transplant (LT) between 2011 and 2015 were obtained from the United Network for Organ Sharing Standard Transplant Analysis and Research file. LTs from noneligible and eligible donors were compared. The proportion of noneligible liver donors by DSA varied significantly, ranging from 0% to 19.6% of total liver grafts used. In transplant programs, the proportion of noneligible liver donors used ranged from 0% to 35.3%. On linear regression there was no correlation between match Model for End-Stage Liver Disease score for programs in a given DSA and proportion of noneligible donors used from the corresponding DSA (p = 0.14). Noneligible donors remain an underutilized resource in many OPOs. Policy changes to begin tracking noneligible donors and learning from OPOs that have high noneligible donor usage are potential strategies to increase awareness and pursuit of these organs.

摘要

器官获取组织 (OPO) 的绩效通常通过器官获取程序数量除以符合条件的死亡人数(<70 岁脑死亡后捐献者 [DBD])来评估,而不符合条件的死亡人数(包括心死亡后捐献者和>70 岁 DBD 捐献者)则未被跟踪。本研究旨在调查 58 个供体服务区域 (DSA) 的非合格肝供体比例的可变性。从美国器官共享网络标准移植分析和研究文件中获得了 2011 年至 2015 年期间接受肝移植 (LT) 的患者。比较了非合格和合格供体的 LT。DSA 之间非合格肝供体的比例差异显著,范围从总使用肝移植物的 0%到 19.6%。在移植项目中,非合格肝供体的使用比例从 0%到 35.3%不等。在线性回归中,特定 DSA 中计划的匹配终末期肝病模型评分与相应 DSA 中使用的非合格供体比例之间没有相关性(p = 0.14)。在许多 OPO 中,非合格供体仍然未得到充分利用。开始跟踪非合格供体的政策变化以及从使用非合格供体比例较高的 OPO 中学习,是提高认识和追求这些器官的潜在策略。

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