80岁以下循环性死亡后器官捐献用于肝移植：再次突破极限。
Controlled donation after circulatory death up to 80 years for liver transplantation: Pushing the limit again.
作者信息
Cascales-Campos Pedro A, Ferreras David, Alconchel Felipe, Febrero Beatriz, Royo-Villanova Mario, Martínez María, Rodríguez José M, Fernández-Hernández Juan Á, Ríos Antonio, Pons José A, Sánchez-Bueno Francisco, Robles Ricardo, Martínez-Barba Enrique, Martínez-Alarcón Laura, Parrilla Pascual, Ramírez Pablo
机构信息
Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain.
出版信息
Am J Transplant. 2020 Jan;20(1):204-212. doi: 10.1111/ajt.15537. Epub 2019 Aug 13.
Our main objective was to compare liver transplant (LT) results between donation after circulatory death (DCD) and donation after brainstem death (DBD) in our hospital and to analyze, within the DCD group, the influence of age on the results obtained with DCD donors aged >70 years and up to 80 years. All DCD-LTs performed were analyzed prospectively. The results of the DCD group were compared with those of a control group who received a DBD-LT immediately after each DCD-LT. Later, the results obtained within the DCD group were analyzed according to the age of the donors, considering 2 subgroups with a cut-off point at 70 years. Survival results for LT with DCD and super rapid recovery were not inferior to those obtained in a similar group of patients transplanted with DBD livers. However, the cost of DCD was a higher rate of biliary complications, including ischemic cholangiopathy. Donor age was not a negative factor.
我们的主要目标是比较我院心脏死亡后器官捐献（DCD）和脑死亡后器官捐献（DBD）的肝移植（LT）结果，并在DCD组内分析年龄对70岁以上至80岁DCD供者所获结果的影响。对所有实施的DCD-LT进行前瞻性分析。将DCD组的结果与每组DCD-LT后立即接受DBD-LT的对照组结果进行比较。随后，根据供者年龄分析DCD组内所获结果，将其分为两个亚组，分界点为70岁。DCD肝移植及超快速恢复的生存结果并不逊于接受DBD肝脏移植的类似患者组。然而，DCD的代价是胆道并发症发生率较高，包括缺血性胆管病。供者年龄并非负面因素。
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