Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210046, China.
State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, China.
Org Lett. 2016 Dec 16;18(24):6496-6499. doi: 10.1021/acs.orglett.6b03435. Epub 2016 Dec 7.
Autoimmune and inflammatory diseases are associated with inappropriate activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, but suitable inhibitors against such improper activations remain scarce. Here, spirodalesol (1) from Daldinia eschscholzii was structurally characterized and is biosynthetically proposed as an NLRP3 inflammasome activation inhibitor with an unprecedented carbon skeleton.
自身免疫和炎症性疾病与 NOD 样受体蛋白 3（NLRP3）炎性小体的不适当激活有关，但针对这种不当激活的合适抑制剂仍然稀缺。在这里，从 Daldinia eschscholzii 中分离得到的螺环倍半萜内酯（1）的结构特征，并被生物合成提出作为一种具有前所未有的碳骨架的 NLRP3 炎性小体激活抑制剂。
