来自……物种的次生代谢产物的结构与生物活性

Structures and Biological Activities of Secondary Metabolites from spp.

作者信息

Yu Miao, Chen Shiji, Shi Jueying, Chen Weikang, Qiu Yikang, Lan Jing, Qu Shiyan, Feng Jiayi, Wang Ru, Lin Fangru, Huang Guolei, Zheng Caijuan

机构信息

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China.

出版信息

J Fungi (Basel). 2024 Dec 2;10(12):833. doi: 10.3390/jof10120833.

DOI:10.3390/jof10120833

PMID:39728329

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677690/

Abstract

The genus have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of from January 1995 to June 2024, and 280 compounds, including six major categories-terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes-are presented in this review. Among these metabolites, 196 were identified as new structures. Remarkably, 112 compounds exhibited a range of biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities. This review highlights the bioactive metabolites discovered in the past three decades from the genus of while also exploring the potential of these symbiotic fungi as rich sources of novel and diverse natural products. The varying bioactivities of these metabolites offer a vast array of promising lead compounds and also could significantly contribute to the development of new medicines.

摘要

长期以来，该属一直被认为是结构新颖、具有药学相关性的天然产物的来源。我们回顾了1995年1月至2024年6月从该属分离出的次生代谢产物的结构和活性，本综述介绍了280种化合物，包括萜类、生物碱、聚酮化合物、多酚、甾体和其他六大类。在这些代谢产物中，196种被鉴定为新结构。值得注意的是，112种化合物表现出一系列生物活性，包括细胞毒性、抗菌、抗炎、抗真菌、抗病毒和酶抑制活性。本综述重点介绍了过去三十年中从该属发现的生物活性代谢产物，同时也探讨了这些共生真菌作为丰富的新型和多样化天然产物来源的潜力。这些代谢产物的不同生物活性提供了大量有前景的先导化合物，也可能对新药的开发做出重大贡献。