Diversified Polyketides With Anti-inflammatory Activities From Mangrove Endophytic Fungus KBJYZ-1.

In total, five new polyketide derivatives: eschscholin B (), dalditone A and B ( and ), (1, 4)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1,4-dio (), and daldilene A (), together with 10 known as analogs (, -) were isolated from the mangrove endophytic fungus KBJYZ-1. Their structures and absolute configurations were established by extensive analysis of NMR and HRESIMS spectra data combined with ECD calculations and the reported literature. Compounds and showed significant cell-based anti-inflammatory activities with IC values of 19.3 and 12.9 μM, respectively. In addition, western blot results suggested that compound effectively inhibits the expression of iNOS and COX-2 in LPS-induced RAW264.7 cells. Further molecular biology work revealed the potential mechanism of exerts anti-inflammatory function by inactivating the MAPK and NF-κB signaling pathways.