Shestakova S A, Stepanian M L
Patol Fiziol Eksp Ter. 1989 May-Jun(3):61-3.
The authors studied thrombin-induced aggregation of blood platelets washed clean of plasma and some parameters of their energetic status (content of ATP, ADP, and glycogen) in rats with acute vasorenal hypertension (AVH). Sensitivity of platelets to thrombin, the inductor of aggregation, was found to be increased and the initial aggregation in rats with AVN accelerated as compared to that in the controls. At the same time, the total adenine nucleotide content in platelets of rats with AVH was reduced--the ATP content by 33% and the glycogen content by 27%. The data obtained provide evidence that there is no correlation between the ATP and glycogen content in rat platelets and their ability for aggregation.
作者研究了急性肾血管性高血压（AVH）大鼠血浆洗净后的血小板的凝血酶诱导聚集及其能量状态的一些参数（ATP、ADP和糖原含量）。与对照组相比，发现血小板对聚集诱导剂凝血酶的敏感性增加，AVN大鼠的初始聚集加速。同时，AVH大鼠血小板中的总腺嘌呤核苷酸含量降低——ATP含量降低33%，糖原含量降低27%。所获得的数据证明，大鼠血小板中的ATP和糖原含量与其聚集能力之间没有相关性。
