Sly P D, Hibbert M E
Department of Thoracic Medicine, Royal Children's Hospital, Melbourne, Australia.
Pediatr Pulmonol. 1989;7(3):153-8. doi: 10.1002/ppul.1950070307.
A prospective follow-up of 48 infants hospitalized with respiratory syncytial virus bronchiolitis in the first year of life revealed that 44 of these infants had symptoms suggestive of asthma in the 5 years following their initial illness (cumulative prevalence 92%). Symptoms became less frequent and less troublesome during the follow-up period. Thirty-five of these children visited the laboratory for clinical examination, pulmonary function testing, and histamine challenge. Twenty-five children were believed to have clinical evidence of asthma at the time of the laboratory visit (point prevalence 71%). Five children were unable to perform pulmonary function tests; 25 of the remaining 30 (67%) had a positive histamine challenge test. No relationship could be demonstrated between a clinical diagnosis of asthma, a family history of atopy, and the results of histamine challenge testing. These results question the relationship between the results of bronchial provocation tests and clinical asthma in this age group.
一项对48名在出生后第一年因呼吸道合胞病毒细支气管炎住院的婴儿进行的前瞻性随访显示，其中44名婴儿在初次患病后的5年内出现了提示哮喘的症状（累积患病率92%）。在随访期间，症状出现的频率降低，程度减轻。其中35名儿童前往实验室进行临床检查、肺功能测试和组胺激发试验。在实验室检查时，25名儿童被认为有哮喘的临床证据（时点患病率71%）。5名儿童无法进行肺功能测试；其余30名儿童中有25名（67%）组胺激发试验呈阳性。哮喘的临床诊断、特应性家族史与组胺激发试验结果之间未显示出相关性。这些结果对该年龄组支气管激发试验结果与临床哮喘之间的关系提出了质疑。
