Brown Shaun R, Cleveland Elane M, Deeken Corey R, Huitron Sonni S, Aluka Kanayochukwu J, Davis Kurt G
Department of General Surgery, William Beaumont Army Medical Center, El Paso, Texas.
Department of General Surgery, William Beaumont Army Medical Center, El Paso, Texas.
J Surg Res. 2017 Jan;207:229-234. doi: 10.1016/j.jss.2016.08.044. Epub 2016 Aug 12.
The incidence of diverticulitis in young patients is rising, whereas the type I:III collagen ratio of the colon decreases with age. Perhaps a lower type I:III collagen ratio in younger patients may predispose these patients to the development of the disease.
The purpose of this study was to evaluate the collagen content and type I:III collagen ratio in patients with diverticulitis versus a control group. Patients who underwent a colon resection were identified. Three groups of patients were created for analysis: those with diverticulitis aged <50 y, >50 y, and a control group. Tissue samples were stained with Sirius red/fast green and photographed. Photos analysis was performed to quantify the amount of type I collagen and type III collagen. The type I:III collagen ratio was calculated for each patient and compared.
The quantity of type I collagen and type III collagen was higher in patients with diverticulitis aged >50 y (P = 0.04 and P < 0.0001, respectively); however, the collagen ratio was greatest in those patients with diverticulitis aged <50 y (P = 0.01). Further analysis demonstrated a significant higher type I:III ratio in all patients aged less than 50 y compared with all patients aged over 50 y (P = 0.04).
Our study demonstrated that diverticulitis in the younger patient was not associated with a lower type I:III collagen ratio. It appears that the decrease in collagen ratio of the colon with age is associated with an increase in type III collagen deposition.
年轻患者憩室炎的发病率正在上升，而结肠的I型：III型胶原蛋白比例随年龄增长而降低。也许年轻患者较低的I型：III型胶原蛋白比例可能使这些患者易患该疾病。
本研究的目的是评估憩室炎患者与对照组的胶原蛋白含量及I型：III型胶原蛋白比例。确定接受结肠切除术的患者。创建三组患者进行分析：年龄<50岁的憩室炎患者、年龄>50岁的憩室炎患者和一个对照组。组织样本用天狼星红/固绿染色并拍照。进行照片分析以量化I型胶原蛋白和III型胶原蛋白的量。计算每位患者的I型：III型胶原蛋白比例并进行比较。
年龄>50岁的憩室炎患者中I型胶原蛋白和III型胶原蛋白的量更高（分别为P = 0.04和P < 0.0001）；然而，年龄<50岁的憩室炎患者的胶原蛋白比例最高（P = 0.01）。进一步分析表明，所有年龄小于50岁的患者的I型：III型比例显著高于所有年龄大于50岁的患者（P = 0.04）。
我们的研究表明，年轻患者的憩室炎与较低的I型：III型胶原蛋白比例无关。似乎结肠胶原蛋白比例随年龄的降低与III型胶原蛋白沉积的增加有关。
