Ritter J, Oehme J
Med Klin. 1978 Sep 29;73(39):1360-2.
Acute myelogenous leukemia 11 years after successful treatment of Hodgkin's disease: A contribution to the problem of second malignancies. The occurence of a therapy resistant acute myelogenous leukemia 11 years after successful treatment (operation, radiotherapy, polychemotherapy) of Hodgkin's disease is described. While this second malignancy was rarely seen in the era of minimal or no therapy of Hodgkin's disease, it is nowadays described more often. The possible causes of this second malignant tumor are discussed. Although modern therapy of Hodgkin's disease should not be abandoned from fear of second malignancies, any change in primary treatment must consider not only acute toxicity but also the occurence of late second malignant tumors. Long term follow-up of all patients treated with radiotherapy and/or polychemotherapy is necessary.
霍奇金淋巴瘤成功治疗11年后发生急性髓系白血病：对第二原发恶性肿瘤问题的一项贡献。本文描述了霍奇金淋巴瘤成功治疗（手术、放疗、多药化疗）11年后出现的对治疗耐药的急性髓系白血病。在霍奇金淋巴瘤极少或无治疗的时代，这种第二原发恶性肿瘤很少见，而如今报道更为常见。讨论了这种第二原发恶性肿瘤的可能病因。虽然不应因担心第二原发恶性肿瘤而放弃霍奇金淋巴瘤的现代治疗，但任何初始治疗的改变不仅要考虑急性毒性，还要考虑晚期第二原发恶性肿瘤的发生。对所有接受放疗和/或多药化疗的患者进行长期随访是必要的。
