Halperin John J
Sidney Kimmel Medical College of Thomas Jefferson University, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA.
Infect Dis Clin North Am. 2017 Mar;31(1):55-68. doi: 10.1016/j.idc.2016.10.005. Epub 2016 Dec 12.
Although patients with Legionnaire's disease frequently develop alterations of consciousness, this is no more frequent than in patients hospitalized with other, equally severe forms of bacterial pneumonia. Legionella meningitis occurs rarely, if ever. Patients with Legionnaire's are susceptible to critical illness polyneuropathy/myopathy, as are other critically ill patients. Legionnaire's patients may develop MRI hyperdensities in the splenium of the corpus callosum, as may other patients with severe infections. Patients with Legionnaire's may be at increased risk of, and rarely develop, immune-mediated multifocal brain (acute disseminated encephalomyelitis) or peripheral nerve disease (Guillain-Barré syndrome).
虽然军团病患者经常出现意识改变，但这并不比因其他同样严重的细菌性肺炎住院的患者更常见。军团菌脑膜炎即使发生也极为罕见。与其他重症患者一样，军团病患者易患危重病性多发性神经病/肌病。军团病患者可能会出现胼胝体压部磁共振成像高密度影，其他严重感染患者也可能如此。军团病患者可能发生免疫介导的多灶性脑疾病（急性播散性脑脊髓炎）或周围神经疾病（吉兰 - 巴雷综合征）的风险增加，但很少发生。
