Htwe Tin Han, Khardori Nancy M
Sentara Infectious Diseases Specialists, Sentara Medical Group, 850 Kempsville Road, Norfolk, VA 23502, USA.
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Hofheimer Hall, 825 Fairfax Avenue, Norfolk, VA 23507, USA.
Infect Dis Clin North Am. 2017 Mar;31(1):29-42. doi: 10.1016/j.idc.2016.10.003. Epub 2016 Dec 12.
Immunosuppressive agents predispose patients to legionnaire's disease. Patients receiving tumor necrosis factor antagonists are generally not severely immunocompromised by the underlying disease. In patients with malignancy receiving immunosuppressive therapies, it is difficult to balance the underlying disease versus the therapy used. Transplant recipients are often on multiple drugs, including immunosuppressants. It seems that immunosuppressive drugs add to the risk for legionella infection. The index of suspicion should be high for legionella infection early during a compatible clinical syndrome. The control of Legionella species and prevention of transmission should be the foremost goal in protecting susceptible populations from Legionnaire's disease.
免疫抑制剂会使患者易患军团菌病。接受肿瘤坏死因子拮抗剂治疗的患者通常不会因基础疾病而严重免疫功能低下。对于接受免疫抑制治疗的恶性肿瘤患者，很难在基础疾病和所用治疗之间取得平衡。移植受者通常服用多种药物，包括免疫抑制剂。免疫抑制药物似乎会增加军团菌感染的风险。在出现符合临床综合征的早期，对军团菌感染的怀疑指数应较高。控制军团菌种类和预防传播应是保护易感人群免受军团菌病侵害的首要目标。
