Lanternier Fanny, Ader Florence, Pilmis Benoit, Catherinot Emilie, Jarraud Sophie, Lortholary Olivier
AP-HP, Hôpital Necker-Enfants malades, Centre d'Infectiologie Necker-Pasteur, IHU Imagine, Université Paris Descartes, 149, rue de Sevres, Paris 75015, France.
Legionelles, Inserm 1111 Centre International Recherche en Infectiologie (CIRI), Université Claude Bernard Lyon 1, Lyon, France; Hospices Civils de Lyon, Lyon, France.
Infect Dis Clin North Am. 2017 Mar;31(1):123-135. doi: 10.1016/j.idc.2016.10.014.
Legionnaire's disease (LD) is mainly reported in apparently immunocompetent patients. Among them, risk factors include chronic lung disease and smoking. However, LD is also well reported among immunocompromised patients, particularly those treated with anti-tumor necrosis factor alpha therapy, patients with hematological malignancy, and transplant patients. This article discusses the available data on immunity against Legionella spp, epidemiology, clinical presentation, diagnosis, and treatment of LD in immunocompromised patients.
军团病（LD）主要在看似免疫功能正常的患者中被报道。其中，危险因素包括慢性肺病和吸烟。然而，LD在免疫功能低下的患者中也有大量报道，特别是那些接受抗肿瘤坏死因子α治疗的患者、血液系统恶性肿瘤患者和移植患者。本文讨论了免疫功能低下患者中针对嗜肺军团菌的免疫、流行病学、临床表现、诊断和治疗的现有数据。
