Cancel Aïda, Comte Magali, Boutet Claire, Schneider Fabien C, Rousseau Pierre-François, Boukezzi Sarah, Gay Aurélia, Sigaud Torrance, Massoubre Catherine, Berna Fabrice, Zendjidjian Xavier Y, Azorin Jean-Michel, Blin Olivier, Fakra Eric
Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France; Department of Psychiatry, University Hospital of Saint-Etienne, Saint-Etienne, France.
Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
Schizophr Res. 2017 Jun;184:69-72. doi: 10.1016/j.schres.2016.12.003. Epub 2016 Dec 13.
Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia.
童年创伤对精神分裂症的情绪反应有强烈影响。我们使用情绪任务期间的广义心理生理交互作用，探讨了早期创伤与杏仁核功能连接之间的关联。研究纳入了21名精神分裂症患者和25名对照者。在精神分裂症患者中，童年期较高水平的性虐待和身体忽视与杏仁核与后扣带回/楔前叶区域之间的连接性降低有关。此外，与对照者相比，患者的杏仁核与后扣带回/楔前叶区域之间的耦合也降低。这些发现表明，早期创伤可能会影响特定应激相关回路中后来的连接性，从而影响精神分裂症患者的自我意识和社会认知。
