Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China.
Soc Cogn Affect Neurosci. 2023 Feb 9;18(1). doi: 10.1093/scan/nsac064.
The present study investigated the effect of childhood trauma (CT) on amygdala and hippocampus functional connectivity (FC) and the association with clinical presentations of major depressive disorder (MDD). Participants included 73 MDD patients (42 with moderate-to-severe CT and 31 with no or low CT) and 64 healthy controls (HC; 30 with moderate-to-severe CT and 34 with no or low CT). Seed-based whole-brain resting-state FC analyses were performed with seeds located in amygdala and hippocampus. Individuals with moderate-to-severe CT, irrespective of MDD diagnosis, had decreased right amygdala-right precuneus connectivity compared to those with no or low CT. Right amygdala-right precuneus connectivity was significantly correlated with physical and social trait anhedonia in MDD. Mediation effects of this FC on relationship between CT (specifically neglect but not abuse) and trait anhedonia in MDD were significant. MDD patients demonstrated increased right amygdala-left middle frontal gyrus FC, decreased right amygdala-right medial superior frontal gyrus (mSFG) FC and decreased right hippocampus-bilateral mSFG FC relative to HC. Findings highlight the effect of CT on right amygdala-right precuneus FC irrespective of MDD diagnosis. FC of right amygdala-right precuneus may be involved in the mechanism linking CT and depression through its association with trait anhedonia.
本研究探讨了儿童创伤（CT）对杏仁核和海马体功能连接（FC）的影响，以及其与重度抑郁症（MDD）临床特征的关联。参与者包括 73 名 MDD 患者（42 名中重度 CT，31 名无或低 CT）和 64 名健康对照者（HC；30 名中重度 CT，34 名无或低 CT）。使用位于杏仁核和海马体的种子点进行基于种子的全脑静息态 FC 分析。与无或低 CT 者相比，无论 MDD 诊断如何，中重度 CT 个体的右侧杏仁核与右侧楔前叶连接减少。右侧杏仁核与右侧楔前叶的连接与 MDD 的躯体和社交特质快感缺失显著相关。这种 FC 在 CT（特别是忽视而不是虐待）与 MDD 特质快感缺失之间的关系中具有显著的中介效应。与 HC 相比，MDD 患者表现出右侧杏仁核与左侧额中回 FC 增加，右侧杏仁核与右侧额上回（mSFG）FC 减少，右侧海马体与双侧 mSFG FC 减少。研究结果强调了 CT 对右侧杏仁核与右侧楔前叶 FC 的影响，无论 MDD 诊断如何。右侧杏仁核与右侧楔前叶的 FC 可能通过与特质快感缺失的关联，参与了 CT 和抑郁之间的联系机制。
