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8年间从一名囊性纤维化患者痰液中分离出的40株铜绿假单胞菌临床菌株的基因组序列草图

Draft Genome Sequences of 40 Pseudomonas aeruginosa Clinical Strains Isolated from the Sputum of a Single Cystic Fibrosis Patient Over an 8-Year Period.

作者信息

Bianconi Irene, D'Arcangelo Silvia, Benedet Mattia, Bailey Kate E, Esposito Alfonso, Piffer Elena, Mariotto Alex, Baldo Ermanno, Dinnella Grazia, Gualdi Paola, Schinella Michele, Donati Claudio, Jousson Olivier

机构信息

Centre for Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Trentino Cystic Fibrosis Support Centre, Rovereto Hospital, Trento, Italy.

出版信息

Genome Announc. 2016 Dec 15;4(6):e01205-16. doi: 10.1128/genomeA.01205-16.

DOI:10.1128/genomeA.01205-16
PMID:27979930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5159563/
Abstract

We report draft genome sequences of 40 Pseudomonas aeruginosa strains, isolated from the sputum of a single cystic fibrosis patient over eight years. Analyses indicated a correlation between multidrug-resistant phenotypes and population structure. Our data provide new insights into the mechanisms leading to acquisition of antibiotic resistance in P. aeruginosa.

摘要

我们报告了从一名囊性纤维化患者八年间痰液中分离出的40株铜绿假单胞菌菌株的基因组序列草图。分析表明多重耐药表型与群体结构之间存在相关性。我们的数据为铜绿假单胞菌获得抗生素耐药性的机制提供了新的见解。

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本文引用的文献

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Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.选择性清除和并行途径适应驱动囊性纤维化肺中铜绿假单胞菌的进化。
mBio. 2015 Sep 1;6(5):e00981-15. doi: 10.1128/mBio.00981-15.
2
Divergent, coexisting Pseudomonas aeruginosa lineages in chronic cystic fibrosis lung infections.慢性囊性纤维化肺部感染中不同的、共存的铜绿假单胞菌谱系。
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Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.在囊性纤维化感染期间，重组是铜绿假单胞菌群体中基因组和表型多样性的关键驱动因素。
Sci Rep. 2015 Jan 12;5:7649. doi: 10.1038/srep07649.
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Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis.铜绿假单胞菌在囊性纤维化患者体内的趋同进化和适应。
Nat Genet. 2015 Jan;47(1):57-64. doi: 10.1038/ng.3148. Epub 2014 Nov 17.
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Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.利用全基因组序列数据预测大肠杆菌和肺炎克雷伯菌分离株的抗菌药物敏感性。
J Antimicrob Chemother. 2013 Oct;68(10):2234-44. doi: 10.1093/jac/dkt180. Epub 2013 May 30.
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Genotyping using whole-genome sequencing is a realistic alternative to surveillance based on phenotypic antimicrobial susceptibility testing.全基因组测序的基因分型是基于表型抗菌药物敏感性试验的监测的一种现实替代方法。
J Antimicrob Chemother. 2013 Apr;68(4):771-7. doi: 10.1093/jac/dks496. Epub 2012 Dec 11.
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SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.SPAdes：一种新的基因组组装算法及其在单细胞测序中的应用
J Comput Biol. 2012 May;19(5):455-77. doi: 10.1089/cmb.2012.0021. Epub 2012 Apr 16.
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Fast gapped-read alignment with Bowtie 2.快速缺口读对准与 Bowtie 2。
Nat Methods. 2012 Mar 4;9(4):357-9. doi: 10.1038/nmeth.1923.
9
Multilocus sequence typing of total-genome-sequenced bacteria.全基因组测序细菌的多位点序列分型。
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10
Pseudomonas aeruginosa: all roads lead to resistance.铜绿假单胞菌：条条大路通耐药。
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