Center of Bacteriology, Instituto Adolfo Lutz, São Paulo, Brazil.
Department of Clinical Analysis, School of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
J Glob Antimicrob Resist. 2017 Mar;8:106-107. doi: 10.1016/j.jgar.2016.11.005. Epub 2017 Jan 7.
Cystic fibrosis (CF) patients are often chronically colonised or infected by non-fermenting Gram-negative bacilli, with Pseudomonas aeruginosa being the most prevalent. In this study, we report the draft genome sequence of a multidrug-resistant P. aeruginosa strain belonging to sequence type ST235, isolated from the respiratory tract of a CF patient with chronic colonisation. Whole-genome sequencing analysis revealed a 6.7Mb genome size and the presence of 12 antibiotic resistance genes, including the rmtG gene conferring high-level aminoglycoside resistance, located on the chromosome.
囊性纤维化 (CF) 患者通常会长期定植或感染非发酵革兰氏阴性杆菌，其中铜绿假单胞菌最为常见。在本研究中，我们报告了一株多药耐药铜绿假单胞菌菌株的基因组草图序列，该菌株属于序列型 ST235，从一名患有慢性定植的 CF 患者的呼吸道中分离得到。全基因组测序分析显示，该菌株的基因组大小为 6.7Mb，并且存在 12 个抗生素耐药基因，包括位于染色体上的赋予高水平氨基糖苷类耐药性的 rmtG 基因。
