Bechara Gustavo Ruschi, Damasceno-Ferreira José Aurelino, Abreu Leonardo Albuquerque Dos Santos, Costa Waldemar Silva, Sampaio Francisco José Barcellos, Pereira-Sampaio Marco Aurélio, Souza Diogo Benchimol De
Master, Postgraduate Program in Physiopathology and Surgical Sciences, Urogenital Research Unit, Universidade Estadual do Rio de Janeiro (UERJ), Brazil. Conception and design of the study, acquisition and interpretation of data, final approval of the manuscript.
Master, Postgraduate Program in Physiopathology and Surgical Sciences, Urogenital Research Unit, UERJ, Rio de Janeiro-RJ. Assistant Professor, Department of Veterinary Clinical Pathology, Universidade Federal Fluminense (UFF), Niteroi-RJ, Brazil. Acquisition and interpretation of data, manuscript preparation, final approval of the manuscript.
Acta Cir Bras. 2016 Nov;31(11):753-758. doi: 10.1590/S0102-865020160110000008.
: To evaluate the glomerular loss after arteriovenous or arterial warm ischemia in a swine model.
: Twenty four pigs were divided into Group Sham (submitted to all surgical steps except the renal ischemia), Group AV (submitted to 30 minutes of warm ischemia by arteriovenous clamping of left kidney vessels), and Group A (submitted to 30 minutes of ischemia by arterial clamping). Right kidneys were used as controls. Weigh, volume, cortical volume, glomerular volumetric density (Vv[Glom]), volume-weighted glomerular volume (VWGV), and the total number of glomeruli were measured for each organ.
: Group AV showed a 24.5% reduction in its left kidney Vv[Glom] and a 25.4% reduction in the VWGV, when compared to the right kidney. Reductions were also observed when compared to kidneys of sham group. There was a reduction of 19.2% in the total number of glomeruli in AV kidneys. No difference was observed in any parameters analyzed on the left kidneys from group A.
: Renal warm ischemia of 30 minutes by arterial clamping did not caused significant glomerular damage, but arteriovenous clamping caused significant glomerular loss in a swine model. Clamping only the renal artery should be considered to minimize renal injury after partial nephrectomies.
在猪模型中评估动静脉或动脉热缺血后的肾小球损失情况。
将24头猪分为假手术组（除肾脏缺血外接受所有手术步骤）、动静脉组（通过夹闭左肾血管进行30分钟热缺血）和动脉组（通过夹闭动脉进行30分钟缺血）。右肾用作对照。测量每个器官的重量、体积、皮质体积、肾小球体积密度（Vv[Glom]）、体积加权肾小球体积（VWGV）以及肾小球总数。
与右肾相比，动静脉组左肾的Vv[Glom]降低了24.5%，VWGV降低了25.4%。与假手术组的肾脏相比也观察到了降低。动静脉组肾脏的肾小球总数减少了19.2%。在动脉组的左肾中，所分析的任何参数均未观察到差异。
在猪模型中，通过夹闭动脉进行30分钟的肾脏热缺血未引起明显的肾小球损伤，但动静脉夹闭导致了明显的肾小球损失。在部分肾切除术后，应考虑仅夹闭肾动脉以尽量减少肾损伤。
