Tsai Sheila C
National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colorado, USA.
Curr Opin Pulm Med. 2017 Mar;23(2):124-128. doi: 10.1097/MCP.0000000000000351.
Sleep related disorders are common and under-recognized in the chronic obstructive pulmonary disease (COPD) population. COPD symptoms can disrupt sleep. Similarly, sleep disorders can affect COPD. This review highlights the common sleep disorders seen in COPD patients, their impact, and potential management.
Treatment of sleep disorders may improve quality of life in COPD patients. Optimizing inhaler therapy improves sleep quality. Increased inflammatory markers are noted in patients with the overlap syndrome of COPD and obstructive sleep apnea versus COPD alone. There are potential benefits of noninvasive positive pressure ventilation therapy for overlap syndrome patients with hypercapnia. Nocturnal supplemental oxygen may be beneficial in certain COPD subtypes. Nonbenzodiazepine hypnotic therapy for insomnia has shown benefit without associated respiratory failure or worsening respiratory symptoms. Melatonin may provide mild hypnotic and antioxidant benefits.
This article discusses the impact of sleep disorders on COPD patients and the potential benefits of managing sleep disorders on respiratory disease control and quality of life.
睡眠相关障碍在慢性阻塞性肺疾病（COPD）人群中很常见且未得到充分认识。COPD症状会扰乱睡眠。同样，睡眠障碍也会影响COPD。本综述重点介绍了COPD患者中常见的睡眠障碍、其影响及潜在的管理方法。
治疗睡眠障碍可能改善COPD患者的生活质量。优化吸入治疗可提高睡眠质量。与单纯COPD患者相比，COPD与阻塞性睡眠呼吸暂停重叠综合征患者的炎症标志物水平升高。对于有高碳酸血症的重叠综合征患者，无创正压通气治疗有潜在益处。夜间补充氧气可能对某些COPD亚型有益。非苯二氮䓬类催眠疗法治疗失眠已显示出益处，且无相关呼吸衰竭或呼吸症状恶化。褪黑素可能具有轻度催眠和抗氧化作用。
本文讨论了睡眠障碍对COPD患者的影响以及管理睡眠障碍对控制呼吸系统疾病和提高生活质量的潜在益处。
