Li Tong, Liu Chengxiu, Yao Yufeng, Yu Jiankun, Shi Li, Shen Yunsong
First People's Hospital of Yunnan Province, Affiliated Kunhua Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Dec 10;33(6):806-810. doi: 10.3760/cma.j.issn.1003-9406.2016.06.013.
To assess the association of single nucleotide polymorphisms (SNPs) of the low molecular weight polypeptide (LMP) gene with chronic hepatitis C virus (HCV) infection among ethnic Han population from Yunnan.
A total of 427 patients with chronic HCV infection and 412 healthy controls were recruited. SNPs rs1351383, rs17587 and rs2127675 from the promoter region of the LMP2 gene and rs2071543 from the promoter region of the LPM7 gene were genotyped using a TaqMan probe. The haplotypes were constructed. Frequencies of various alleles, genotypes and haplotypes of the selected SNPs were calculated, and their association with chronic HCV infection was analyzed.
The frequencies of rs1351383 and rs2127675 alleles of the LMP2 gene, as well as the A-G-A and C-G-G haplotypes of the rs1351383/rs17587/rs2127675 loci, had differed significantly between the two groups (P<0.05).
The C allele of the rs1351383 locus and G allele of the rs2217675 locus of the LMP2 gene may be susceptible factors for chronic HCV infection among ethnic Han people from Yunnan. The A-G-A haplotype of the rs1351383/rs17587/rs2127675 loci may confer a protective effect, while the C-G-G haplotype may be a susceptible factor for chronic HCV infection in this population.
评估低分子量多肽（LMP）基因单核苷酸多态性（SNP）与云南汉族人群慢性丙型肝炎病毒（HCV）感染的相关性。
共招募427例慢性HCV感染患者和412例健康对照。使用TaqMan探针检测LMP2基因启动子区域的SNP rs1351383、rs17587和rs2127675以及LPM7基因启动子区域的SNP rs2071543的基因型。构建单倍型。计算所选SNP的各种等位基因、基因型和单倍型频率，并分析它们与慢性HCV感染的相关性。
两组间LMP2基因的rs1351383和rs2127675等位基因频率，以及rs1351383/rs17587/rs2127675位点的A-G-A和C-G-G单倍型频率存在显著差异（P<0.05）。
LMP2基因的rs1351383位点的C等位基因和rs2217675位点的G等位基因可能是云南汉族人群慢性HCV感染的易感因素。rs1351383/rs17587/rs2127675位点的A-G-A单倍型可能具有保护作用，而C-G-G单倍型可能是该人群慢性HCV感染的易感因素。
