Rose J E, Sampson A, Levin E D, Henningfield J E
VA Medical Center, Durham, NC 27705.
Pharmacol Biochem Behav. 1989 Apr;32(4):933-8. doi: 10.1016/0091-3057(89)90061-0.
Eight subjects evaluated various qualities of cigarette smoke after being given a range of doses (0, 2.5, 10 and 20 mg) of the nicotinic receptor blocker mecamylamine. In one test condition, subjects were given either high or low nicotine tobacco smoke to determine the effects of mecamylamine on their subjective responses. In another test condition, subjects were allowed to adjust the nicotine dose level of the smoke to determine the effects of mecamylamine on dose preference. When the subjects evaluated puffs of smoke with high and low nicotine content, mecamylamine caused a dose-related decrease in the self-rated strength and harshness of the high nicotine dose level smoke. In contrast, there was little effect on the low dose smoke. At the highest mecamylamine dose (20 mg) there was no significant difference in the ratings of high and low nicotine cigarettes. Low doses of mecamylamine decreased the reported desire for a cigarette, and also attenuated the reduction in desire for a cigarette caused by smoking. When the subjects were allowed to select their preferred level of nicotine intake using a smoke mixing device, the 10 and 20 mg doses of mecamylamine caused a significant increase in self-administered nicotine dose level. Despite this compensatory increase in nicotine self-administration, the reduction in desire for a cigarette after smoking was still less than after placebo.
八名受试者在服用一系列剂量（0、2.5、10和20毫克）的烟碱受体阻滞剂美加明后，对香烟烟雾的各种特性进行了评估。在一种测试条件下，受试者被给予高尼古丁或低尼古丁烟草烟雾，以确定美加明对其主观反应的影响。在另一种测试条件下，受试者被允许调整烟雾中的尼古丁剂量水平，以确定美加明对剂量偏好的影响。当受试者评估高尼古丁含量和低尼古丁含量的烟雾抽吸时，美加明导致高尼古丁剂量水平烟雾的自我评定强度和刺激性出现剂量相关的降低。相比之下，对低剂量烟雾几乎没有影响。在美加明的最高剂量（20毫克）下，高尼古丁香烟和低尼古丁香烟的评分没有显著差异。低剂量的美加明降低了报告的吸烟欲望，也减弱了吸烟导致的吸烟欲望降低。当受试者使用烟雾混合装置选择他们偏好的尼古丁摄入量水平时，10毫克和20毫克剂量的美加明导致自我给药的尼古丁剂量水平显著增加。尽管尼古丁自我给药有这种代偿性增加，但吸烟后对香烟的欲望降低仍低于服用安慰剂后。
