Nemeth-Coslett R, Henningfield J E, O'Keeffe M K, Griffiths R R
Psychopharmacology (Berl). 1986;88(4):420-5. doi: 10.1007/BF00178502.
Multiple measures of cigarette smoking, subjective effect and physiological effect were collected during 90-min test sessions in normal volunteers. Before sessions subjects received oral doses of mecamylamine (2.5, 5.0, 10, 20 mg) or placebo. Each dose and placebo was given three times in a randomized block sequence. Mecamylamine increased several measures of cigarette smoking, including number of cigarettes, number of puffs per cigarette, and expired air carbon monoxide level. Mecamylamine also produced modest, dose-related decreases in standing blood pressure and increases in standing heart rate. The subjective effects produced by mecamylamine were not characteristic of those of psychoactive drugs. Mecamylamine appears to have increased cigarette smoking by decreasing the effective dose level of nicotine available from cigarette smoking.
在对正常志愿者进行的90分钟测试过程中，收集了多种吸烟指标、主观效应和生理效应。在测试前，受试者口服了不同剂量的美加明（2.5毫克、5.0毫克、10毫克、20毫克）或安慰剂。每种剂量和安慰剂均按照随机区组序列给予三次。美加明增加了多项吸烟指标，包括吸烟支数、每支烟的吸数以及呼出气体中的一氧化碳水平。美加明还使站立位血压出现适度的、与剂量相关的下降，并使站立位心率升高。美加明产生的主观效应并非精神活性药物所具有的典型效应。美加明似乎是通过降低吸烟可获得的尼古丁有效剂量水平来增加吸烟量的。
