环状RNA谱鉴定出circPVT1作为胃癌中的增殖因子和预后标志物。
Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.
作者信息
Chen Jie, Li Yan, Zheng Qiupeng, Bao Chunyang, He Jian, Chen Bin, Lyu Dongbin, Zheng Biqiang, Xu Yu, Long Ziwen, Zhou Ye, Zhu Huiyan, Wang Yanong, He Xianghuo, Shi Yingqiang, Huang Shenglin
机构信息
Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Department of Gastric Cancer and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
出版信息
Cancer Lett. 2017 Mar 1;388:208-219. doi: 10.1016/j.canlet.2016.12.006. Epub 2016 Dec 13.
Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. Our findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC.
环状RNA（circRNAs）是一类新型的广泛存在的非编码RNA，可能在真核生物中调控基因表达。然而，circRNAs在人类癌症中的特征和功能仍不清楚。在此，我们鉴定出至少5500个不同的circRNA候选物以及一系列在胃癌（GC）组织中与配对的正常组织相比差异表达的circRNAs。我们进一步鉴定了一个源自PVT1基因的circRNA，并将其命名为circPVT1。circPVT1的表达在GC组织中常因其基因组位点的扩增而上调。circPVT1可能通过充当miR-125家族成员的海绵来促进细胞增殖。circPVT1的水平被视为GC患者总生存和无病生存的独立预后标志物。我们的研究结果表明，circPVT1是GC中一种新型的增殖因子和预后标志物。
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