Measelle Jeffrey R, David Jason, Ablow Jennifer C
University of Oregon, United States.
University of Oregon, United States.
Behav Brain Res. 2017 May 15;325(Pt B):260-267. doi: 10.1016/j.bbr.2016.12.001. Epub 2016 Dec 13.
Early life adversity is associated with adult elevations of inflammatory markers such as circulating levels of C-reactive protein (CRP). Few studies have examined inflammation levels during infancy nor the associations between sources of adversity and concurrent inflammation early in life. Existing evidence suggests that early adversity in the form of compromised caregiving relationships can embed itself into young children's biology with implications for lifelong development. This study examined the association between infants' histories of attachment with their mothers and salivary concentrations of CRP, all of which were assessed when infants were 17 months of age. Results show that infants with disorganized attachments histories and those exhibiting disorganized and avoidant regulatory behaviors when faced with an attachment stressor were all associated with significantly elevated levels of salivary CRP. These results suggest that exposure to significant interpersonal adversity very early in life may engender a proinflamotry phenotype with life-long implications for health.
早年生活逆境与成年期炎症标志物升高有关，如循环中C反应蛋白（CRP）水平。很少有研究考察婴儿期的炎症水平，也鲜有研究探讨逆境来源与生命早期同时出现的炎症之间的关联。现有证据表明，以受损的照料关系形式存在的早期逆境会融入幼儿的生理机能，对其终身发展产生影响。本研究考察了婴儿与母亲的依恋史和唾液中CRP浓度之间的关联，所有这些都是在婴儿17个月大时进行评估的。结果显示，有混乱依恋史的婴儿以及在面对依恋应激源时表现出混乱和回避调节行为的婴儿，其唾液CRP水平均显著升高。这些结果表明，生命早期暴露于重大人际逆境可能会引发一种促炎表型，对健康产生终身影响。
