Wang Siqi, Jin Haifeng, Tang Qiuqiong, Fu Jun, Ren Zeming, Peng Cike, Shang Lanqin, Hao Weidong, Wei Xuetao
Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
Department of Toxicology, School of Public Health, Peking University, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.
Environ Toxicol Pharmacol. 2017 Jan;49:119-123. doi: 10.1016/j.etap.2016.12.007. Epub 2016 Dec 12.
Ethephon can liberate ethylene which could interfere the plant growth process. The aim of the present study was to determine the effect of ethephon on developing immune system of male offspring. Ethephon could enhance NK cell activity in male mice. For 4-week-old male mice, lymphocytes of peripheral blood increased while the hemolytic plaque number decreased. Delayed type hypersensitivity(DTH) was inhibited in all groups. The expression of protein Bcl11b and p-p38 in thymus of treatment groups were lower than control group. Our results indicated that cellular immunity of male offspring is more sensitive to ethephon when exposed in pregnancy and lactation period. It should be emphasized that exposure to ethephon during the in utero stage and lactation stage still could damage the immune function of animal in the period before fully mature even in the dosage that could not influence the immune function of adult animal.
乙烯利能够释放乙烯，而乙烯会干扰植物的生长过程。本研究的目的是确定乙烯利对雄性后代免疫系统发育的影响。乙烯利可增强雄性小鼠的自然杀伤（NK）细胞活性。对于4周龄的雄性小鼠，外周血淋巴细胞数量增加，而溶血空斑数减少。所有组的迟发型超敏反应（DTH）均受到抑制。治疗组胸腺中蛋白质Bcl11b和磷酸化p38的表达低于对照组。我们的结果表明，雄性后代在孕期和哺乳期接触乙烯利时，其细胞免疫更为敏感。应当强调的是，即使在不会影响成年动物免疫功能的剂量下，在子宫内阶段和哺乳期接触乙烯利仍可能损害动物在完全成熟前这段时期的免疫功能。
