晚发性癫痫患者阻塞性睡眠呼吸暂停综合征的高发病率。

High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy.

作者信息

Maurousset Aude, De Toffol Bertrand, Praline Julien, Biberon Julien, Limousin Nadège

机构信息

Department of neurology, Inserm U930, university hospital Bretonneau, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.

出版信息

Neurophysiol Clin. 2017 Feb;47(1):55-61. doi: 10.1016/j.neucli.2016.11.002. Epub 2016 Dec 14.

DOI:10.1016/j.neucli.2016.11.002

PMID:27988205

Abstract

OBJECTIVES

The objective of the present study was to evaluate the prevalence of obstructive sleep apnea (OSA) in patients with late-onset epilepsy (LOE) who were considered at higher risk of cardiovascular disease.

METHODS

Polysomnography was performed on 27 patients with LOE. Berlin questionnaires and Epworth sleepiness score were performed on all patients. We compared clinical, demographic and anthropometric characteristics, questionnaire scores on the patients with no or mild OSA (group 1) and the patients with moderate or severe OSA (group 2). Patients eligible for continuous positive airway pressure (CPAP) therapy were reviewed in consultation.

RESULTS

Twenty-four patients (88.9%) had OSA and 55.6% had moderate or severe OSA. Patients in group 2 (n=15) were older than patients in group 1 (n=12). The two groups were similar in terms of body mass index (BMI), neck circumference, nocturnal seizure frequency, vascular cardiovascular risk factors and excessive daytime sleepiness. Leukoaraiosis in MRI was highly prevalent in our patients (40.7%), especially in group 2 patients. Eighty percent of the patients who had begun CPAP therapy experienced decreased seizure frequency.

CONCLUSION

Patients with LOE should be screened for the presence of OSA and treated accordingly.

摘要

目的

本研究的目的是评估晚发性癫痫（LOE）患者中阻塞性睡眠呼吸暂停（OSA）的患病率，这些患者被认为具有较高的心血管疾病风险。

方法

对27例LOE患者进行了多导睡眠图检查。对所有患者进行了柏林问卷和爱泼华嗜睡量表评分。我们比较了无或轻度OSA患者（第1组）和中度或重度OSA患者（第2组）的临床、人口统计学和人体测量学特征、问卷评分。对符合持续气道正压通气（CPAP）治疗条件的患者进行了会诊评估。

结果

24例患者（88.9%）患有OSA，55.6%患有中度或重度OSA。第2组（n = 15）患者比第1组（n = 12）患者年龄更大。两组在体重指数（BMI）、颈围、夜间癫痫发作频率、血管心血管危险因素和白天过度嗜睡方面相似。MRI显示的脑白质疏松症在我们的患者中非常普遍（40.7%），尤其是在第2组患者中。开始CPAP治疗的患者中有80%癫痫发作频率降低。