边缘型人格障碍的睡眠表型:系统评价和荟萃分析。

The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis.

机构信息

Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, UK.

Department of Psychology, University of Warwick, UK.

出版信息

Neurosci Biobehav Rev. 2017 Feb;73:48-67. doi: 10.1016/j.neubiorev.2016.12.008. Epub 2016 Dec 15.

Abstract

AIM

To delineate the sleep profile of Borderline Personality Disorder (BPD).

METHOD

A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.

RESULTS

We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.

CONCLUSION

BPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder.

摘要

目的

描绘边缘型人格障碍(BPD)的睡眠模式。

方法

对 BPD 的客观和主观睡眠特征进行综合分析的荟萃分析。

结果

我们确定了 1980 年至 2015 年 12 月期间发表的 32 项研究。荟萃分析表明,BPD 与健康对照组之间在客观睡眠连续性(入睡潜伏期、总睡眠时间、睡眠效率)和结构(快速眼动潜伏期/密度、慢波睡眠)以及自我报告的睡眠问题(噩梦、睡眠质量)方面存在显著差异。这些发现与抑郁(在临床和社区人群中)以及同时使用精神药物无关。BPD 与临床(多数抑郁)对照组之间的差异很小。

结论

BPD 与抑郁观察到的睡眠障碍相当。这些障碍不仅仅是由于共病性抑郁所致。鉴于越来越多的证据表明睡眠障碍可能会加剧情绪失调和自杀风险,BPD 的治疗方法应明确解决睡眠问题。未来的研究应采用前瞻性设计来确定(在何种情况下)睡眠问题是否先于或后于疾病的发作。

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