Huang Jingshan, Eilbeck Karen, Smith Barry, Blake Judith A, Dou Dejing, Huang Weili, Natale Darren A, Ruttenberg Alan, Huan Jun, Zimmermann Michael T, Jiang Guoqian, Lin Yu, Wu Bin, Strachan Harrison J, de Silva Nisansa, Kasukurthi Mohan Vamsi, Jha Vikash Kumar, He Yongqun, Zhang Shaojie, Wang Xiaowei, Liu Zixing, Borchert Glen M, Tan Ming
School of Computing, University of South Alabama, Shelby Hall, Room 1123, 150 Jaguar Drive Mobile, AL 36688, USA,
Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA,
Int J Data Min Bioinform. 2016;15(3):214-232. doi: 10.1504/IJDMB.2016.077072.
Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data.
在过去十年中,非编码RNA(ncRNA)的识别有了显著改进。另一方面,由于缺乏一个全面的本体作为该领域的通用数据元素和数据交换标准,ncRNA数据的语义注释面临着严峻挑战。我们开发了非编码RNA本体(NCRO)来应对这种情况。通过提供一个形式化定义的ncRNA控制词汇表,NCRO旨在填补大量ncRNA生物学和临床数据语义注释中一个特定且急需的空白。