Huang Jingshan, Eilbeck Karen, Smith Barry, Blake Judith A, Dou Dejing, Huang Weili, Natale Darren A, Ruttenberg Alan, Huan Jun, Zimmermann Michael T, Jiang Guoqian, Lin Yu, Wu Bin, Strachan Harrison J, He Yongqun, Zhang Shaojie, Wang Xiaowei, Liu Zixing, Borchert Glen M, Tan Ming
School of Computing, University of South Alabama, Mobile, Alabama, 36688-0002 USA.
Department of Biomedical Informatics, University of Utah, Salt Lake City, 84112-5775 Utah USA.
J Biomed Semantics. 2016 May 4;7:24. doi: 10.1186/s13326-016-0066-0. eCollection 2016.
In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users, accessible at: http://purl.obolibrary.org/obo/ncro.owl.
近年来，测序技术已使人们能够鉴定出种类繁多的非编码RNA（ncRNA）。遗憾的是，ncRNA数据的注释和整合工作落后于其鉴定工作。鉴于该领域获取的信息量巨大，迫切需要整合众多相关群体的发现成果。为此，非编码RNA本体（NCRO）正在开发之中，旨在为ncRNA领域提供一个系统结构化且定义精确的受控词汇表，从而促进有关ncRNA结构、其分子和细胞功能以及其对表型影响的数据的发现、整理、分析、交换及推理。NCRO的目标是以一种能显著增强对目前分散存于不同来源的大量资源进行综合和比较分析的方式，作为各种研究注释的通用资源。我们相信，NCRO本体能够在ncRNA生物学的全面统一中发挥重要作用，并且确实能填补开放生物和生物医学本体（OBO）库以及国家生物医学本体中心（NCBO）生物门户中的关键空白。我们最初的重点是小调控ncRNA的本体表示，我们将其视为为所有形式的ncRNA数据注释提供资源的第一步。NCRO本体对所有用户免费开放，可通过以下网址访问：http://purl.obolibrary.org/obo/ncro.owl。
