Chu M, Nguyen T T, Lee E K, Morival J L, Khine M
Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.
Department of Chemical Engineering, University of California, Irvine, CA 92697, USA.
Lab Chip. 2017 Jan 17;17(2):267-273. doi: 10.1039/c6lc01338d.
We demonstrate a facile, plasma free process to fabricate both reversibly and irreversibly sealed microfluidic chips using a PDMS-based adhesive polymer mixture. This is a versatile method that is compatible with current PDMS microfluidics processes. It allows for easier fabrication of multilayer microfluidic devices and is compatible with micropatterning of proteins for cell culturing. When combined with our Shrinky-Dink microfluidic prototyping, complete microfluidic device fabrication can be performed without the need for any capital equipment, making microfluidics accessible to the classroom.
我们展示了一种简便的、无需等离子体的工艺，该工艺使用基于聚二甲基硅氧烷（PDMS）的粘性聚合物混合物来制造可逆和不可逆密封的微流控芯片。这是一种通用方法，与当前的PDMS微流控工艺兼容。它使得多层微流控设备的制造更加容易，并且与用于细胞培养的蛋白质微图案化兼容。当与我们的“收缩片”微流控原型制作相结合时，无需任何大型设备即可完成完整的微流控设备制造，从而使微流控技术能够进入课堂。
