Hänny P, Müller F
Schweiz Rundsch Med Prax. 1989 Sep 5;78(36):956-9.
VEP- and MRI-changes were compared in 93 patients with definite or probable multiple sclerosis. A high correlation between slowing of visual conduction time and volume of peri-ventricular white matter lesions was found. The finding suggests a retrogenicular site of the pathogenic process being frequently responsible for VEP-abnormalities. Long-standing clinical courses show better VEP/MRI-correlations even without clinical symptoms, whereas acute cases more often have related visual disabilities but no convincing correlations. VEP represent one function of those regions in the brain which are frequently impaired by the demyelinating process in multiple sclerosis. They provide an optimal parameter of clinical course.
对93例确诊或疑似多发性硬化症患者的视觉诱发电位（VEP）和磁共振成像（MRI）变化进行了比较。发现视觉传导时间减慢与脑室周围白质病变体积之间存在高度相关性。这一发现表明，致病过程的网状后部位常常导致VEP异常。病程较长的病例，即使没有临床症状，VEP与MRI的相关性也更好，而急性病例更常伴有相关的视觉障碍，但没有令人信服的相关性。VEP代表了大脑中那些在多发性硬化症脱髓鞘过程中经常受损的区域的一种功能。它们为临床病程提供了一个最佳参数。
