遗传密码的起源：基于tRNA结构、序列和动力学校对的一个可检验的假说
Origin of the genetic code: a testable hypothesis based on tRNA structure, sequence, and kinetic proofreading.
作者信息
Hopfield J J
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4334-8. doi: 10.1073/pnas.75.9.4334.
Abstract
We hypothesize that the origin of the genetic code is associated with the structure of the tRNA that existed in primal cells. The sequences of modern tRNA contain correlations which can be understood as "fossil" evidence of the secondary structure of primal tRNA. Kinetic proofreading through diffusion can amplify a low level of intrinsic selectivity of tRNA for its amino acid. Experimental tests of the theory are suggested.
摘要
我们推测遗传密码的起源与原始细胞中存在的tRNA结构相关。现代tRNA的序列包含一些关联，这些关联可被理解为原始tRNA二级结构的“化石”证据。通过扩散进行的动力学校对可以放大tRNA对其氨基酸的低水平内在选择性。文中还提出了该理论的实验测试方法。
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