Laboratory of Molecular Bases of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Int J Mol Sci. 2021 Mar 27;22(7):3478. doi: 10.3390/ijms22073478.
The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells.
调控染色质组织的能力在神经元中尤为重要，神经元可以对外部刺激做出动态响应。越来越多的证据表明，lncRNA 在组织不同的核域方面发挥着重要的结构作用，如失活的 X 染色体、剪接斑点、核斑和 Gomafu 核体。lncRNA 在神经系统中大量表达，它们可能在细胞核的区室化中发挥重要作用。在这篇综述中，我们将描述 lncRNA 在神经元细胞核中的结构作用。
