Ghoreishi Seyedeh Masoomeh, Khalaj Ali, Bitarafan-Rajabi Ahmad, Azar Amir Darbandi, Ardestani Mehdi Shafiee, Assadi Artin
Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Nuclear Medicine, Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Drug Res (Stuttg). 2017 Mar;67(3):149-155. doi: 10.1055/s-0042-118448. Epub 2016 Dec 19.
Chlorambucil (CBL) is an alkylating agent, which widely use in the treatment of various types of tumors. The main purpose of this study is to evaluate the in-vivo biodistribution of CBL conjugated to the anionic dendrimer, which has a great ability to labeled with Tc through binding to carboxylate terminate groups. Whole body scans were used to analyze the percentage of the injected dose in different times. Radiochemical purity (RCP) and in-vivo biodistribution were also calculated with the SPECT/CT instrument. Our study proposes a new method for RCP determination and shows that this carrier is a promising agent to complex with the Tc and biological assessment.
苯丁酸氮芥（CBL）是一种烷化剂，广泛用于治疗各种类型的肿瘤。本研究的主要目的是评估与阴离子树枝状大分子偶联的CBL的体内生物分布，该阴离子树枝状大分子通过与羧酸盐末端基团结合具有很强的用锝标记的能力。使用全身扫描分析不同时间注射剂量的百分比。还使用SPECT/CT仪器计算放射化学纯度（RCP）和体内生物分布。我们的研究提出了一种测定RCP的新方法，并表明这种载体是一种与锝络合和进行生物学评估的有前景的试剂。
