Katayama Osamu, Osumi Michihiro, Kodama Takayuki, Morioka Shu
Department of Neurorehabilitation, Graduate School of Health Sciences, Kio University, Nara; Department of Rehabilitation, Watanabe Hospital, Aichi.
Department of Neurorehabilitation Research Center, Kio University, Nara.
J Pain Res. 2016 Dec 8;9:1197-1204. doi: 10.2147/JPR.S122564. eCollection 2016.
Pathological pain such as phantom limb pain is caused by sensorimotor incongruence. Several studies with healthy participants have clearly indicated that dysesthesia, which is similar to pathological pain, is caused by incongruence between proprioception and/or motor intention and visual feedback. It is not clear to what extent dysesthesia may be caused by incongruence between motor intention and visual feedback or by incongruence between proprioception and visual feedback. The aim of this study was to clarify the neurophysiology of these factors by analyzing electroencephalograms (EEGs).
In total, 18 healthy participants were recruited for this study. Participants were asked to perform repetitive flexion/extension exercises with their elbows in a congruent/incongruent position while viewing the activity in a mirror. EEGs were performed to determine cortical activation during sensorimotor congruence and incongruence.
In the high-frequency alpha band (10-12 Hz), numeric rating scale scores of a feeling of peculiarity were significantly correlated with event-related desynchronization/synchronization under the incongruence and proprioception conditions associated with motor intention and visual feedback (right inferior parietal region; =-0.63, <0.01) and between proprioception and visual feedback (right temporoparietal region; =-0.49 and =-0.50, <0.05). In these brain regions, there was a region in which incongruence between proprioception and visual feedback and between motor intention and visual feedback caused an increase in activity.
The present findings suggest that neural mechanisms of dysesthesia are caused by incongruence between proprioception associated with motor intention and visual feedback and, in particular, are a result of incongruence between proprioception only and visual feedback.
诸如幻肢痛之类的病理性疼痛是由感觉运动不一致引起的。多项针对健康参与者的研究已明确表明，与病理性疼痛相似的感觉异常是由本体感觉和/或运动意图与视觉反馈之间的不一致所导致的。目前尚不清楚感觉异常在多大程度上可能是由运动意图与视觉反馈之间的不一致引起的，还是由本体感觉与视觉反馈之间的不一致引起的。本研究的目的是通过分析脑电图（EEG）来阐明这些因素的神经生理学机制。
本研究共招募了18名健康参与者。要求参与者在观看镜子中的活动时，将肘部置于一致/不一致的位置进行重复的屈伸运动。通过脑电图来确定感觉运动一致和不一致期间的皮层激活情况。
在高频阿尔法波段（10 - 12赫兹），奇特感的数字评分量表得分与在与运动意图和视觉反馈相关的不一致和本体感觉条件下（右顶下区域；=-0.63，<0.01）以及本体感觉与视觉反馈之间（右颞顶区域；=-0.49和=-0.50，<0.05）的事件相关去同步化/同步化显著相关。在这些脑区中，存在一个区域，其中本体感觉与视觉反馈之间以及运动意图与视觉反馈之间的不一致会导致活动增加。
目前的研究结果表明，感觉异常的神经机制是由与运动意图相关的本体感觉和视觉反馈之间的不一致引起的，特别是仅本体感觉与视觉反馈之间的不一致的结果。
