Kim Hyun-Jung, Sung Lucky, Kim Jung-Yeon, Park Kyeongmee
Address: Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul, Korea.
Department of Urology, Inje University, Sanggye Paik Hospital, Seoul, Korea.
Cytojournal. 2016 Nov 16;13:26. doi: 10.4103/1742-6413.194162. eCollection 2016.
Atypical urine cytology (CYT) triggers a cystoscopic or another ancillary investigation that targets urothelial neoplasms. We report a case presenting as an unknown primary malignancy, which illustrated the diagnostic utility of direct double immunostaining for cytokeratin 20 (CK20)/p53 expression in a urine CYT specimen. A 42-year-old woman visited the emergency room for pain in her right lower abdominal quadrant. Computed tomography revealed postrenal obstructive hydronephrosis, and her urine CYT showed malignancy, type undetermined. Atypical cells that are positive for cytoplasmic expression of CK20 and nuclear expression of p53 could facilitate the decision to perform a nephroureterectomy for urothelial carcinoma.
非典型尿细胞学检查（CYT）会引发针对尿路上皮肿瘤的膀胱镜检查或其他辅助检查。我们报告了一例表现为原发灶不明恶性肿瘤的病例，该病例说明了在尿CYT标本中直接双重免疫染色检测细胞角蛋白20（CK20）/p53表达的诊断效用。一名42岁女性因右下腹部疼痛就诊于急诊室。计算机断层扫描显示肾后梗阻性肾积水，其尿CYT显示为恶性肿瘤，类型未确定。CK20胞质表达和p53核表达呈阳性的非典型细胞有助于决定是否对尿路上皮癌进行肾输尿管切除术。
