Jahadi Hosseini Seyed Hamid Reza, Abtahi Seyed Mohammad Bagher, Khalili Mohammad Reza
Poostchi Eye Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):350-357. doi: 10.4103/2008-322X.194069.
To evaluate the changes and predictability of higher order aberrations (HOAs) after personalized laser keratomileusis (LASIK) and personalized photorefractive keratectomy (PRK) for simple myopia and compound myopic astigmatism.
In this prospective cross-sectional study, 100 eyes were included. A total of 50 eyes underwent personalized LASIK and 50 eyes underwent personalized PRK. Preoperative and postoperative wavefront data were compared between the two groups. The influential factors and predictability of HOAs were also assessed.
Total HOA increased in the amount of 0.01 ± 0.14 μm for the 5 mm pupil ( = 0.55) and 0.08 ± 0.22 μm for the 6 mm pupil ( = 0.02) after PRK; however after LASIK the corresponding values for the 5 and 6 mm pupil sizes were 0.05 ± 0.12 and 0.15 ± 0.18 μm, respectively ( < 0. 001). Mean changes were not significantly different between the PRK and LASIK groups for both 5 and 6 mm pupil sizes ( = 0.21 and = 0.13, respectively). Spherical aberration increased following LASIK more than following PRK ( < 0.001). Changes in the root mean square (RMS) of total HOA had a statistically significant negative correlation ( < 0.001) with its preoperative value. HOA and spherical aberration reduced in majority of eyes when the preoperative spherical equivalent refraction was low.
For the 6mm pupil size, the total HOA increased following both personalized PRK and LASIK with no significant difference between the two groups. Change of the total HOA RMS was influenced by the preoperative values. The known influencing factors could predict nearly 50% of the changes in total HOA.
评估个体化准分子激光原位角膜磨镶术（LASIK）和个体化准分子激光角膜切削术（PRK）治疗单纯性近视和复合性近视散光后高阶像差（HOAs）的变化及可预测性。
在这项前瞻性横断面研究中，纳入了100只眼。其中50只眼接受了个体化LASIK，50只眼接受了个体化PRK。比较两组术前和术后的波前数据。还评估了HOAs的影响因素和可预测性。
PRK术后，5mm瞳孔时总HOA增加了0.01±0.14μm（P = 0.55），6mm瞳孔时增加了0.08±0.22μm（P = 0.02）；然而LASIK术后，5mm和6mm瞳孔大小对应的数值分别为0.05±0.12μm和0.15±0.18μm（P < 0.001）。5mm和6mm瞳孔大小在PRK组和LASIK组之间的平均变化无显著差异（分别为P = 0.21和P = 0.13）。LASIK术后球差增加比PRK术后更明显（P < 0.001）。总HOA的均方根（RMS）变化与其术前值具有统计学显著的负相关性（P < 0.001）。当术前等效球镜度较低时，大多数眼中的HOA和球差会降低。
对于6mm瞳孔大小，个体化PRK和LASIK术后总HOA均增加，两组之间无显著差异。总HOA RMS的变化受术前值影响。已知的影响因素可预测近50%的总HOA变化。
