Giner Serret Emilio
Servicio de Reumatología, Hospital Obispo Polanco, Teruel, Spain.
Case Rep Rheumatol. 2016;2016:1718309. doi: 10.1155/2016/1718309. Epub 2016 Nov 22.
Digital ulcers are a burdensome and painful condition with sparse options of treatment. We report the case of a 78-year-old female patient with limited cutaneous systemic sclerosis that sequentially developed digital ulcers. After the appearance of digital ulcers in the soles of her feet she was successfully treated with bosentan. The report of two new digital ulcers in her hands 9 months later alongside with elevated transaminase levels led to a switch to macitentan treatment. A swift and complete healing of both digital ulcers was observed after 3 months, with the restoration of normal biochemical values.
指端溃疡是一种负担沉重且疼痛的病症，治疗选择有限。我们报告了一例78岁的女性局限性皮肤型系统性硬化症患者，该患者先后出现指端溃疡。在其足底出现指端溃疡后，使用波生坦治疗取得成功。9个月后，她双手出现两个新的指端溃疡，同时转氨酶水平升高，于是改用马西替坦治疗。3个月后观察到两个指端溃疡迅速完全愈合，生化指标恢复正常。
